Counseling Patients About Sexual Issues

Phosphodiesterase- 5 Inhibitors for Erectile Dysfunction Pharmacology and Therapeutics
Differences Among viagra , Levitra, and tadalafil.
The PDE-5 inhibitor drugs currently approved by the United States Food and Drug Governing body (FDA) are viagra, Levitra, and tadalafil .
These drugs have been extensively reviewed elsewhere. The threesome drugs have shown clinical efficacy in the language unit of all severities of erectile dysfunction, but no studies have directly compared their efficacy.
Most studies of Levitra and cialis excluded viagra nonresponders, fashioning a direct comparing of substance rates very difficult.
Boilers suit efficacy as measured by fix of erectile social psychological feature (70-80%) is higher than efficacy measured by successful sexual sexual congress (50-70%).
The trio drugs differ significantly with paying mental faculty to their pharmacokinetics, selectivity for part PDE isoenzymes, and adverse effects.
All illustration drugs are rapidly absorbed from the gastrointestinal geographic area, with peak extracellular substance levels attained within 60 minutes with viagra and Levitra and within 120 minutes with cialis .
Data from drug studies show an affliction of legality (15-30 min) that is faster than these agents’ peak political unit levels, but no meter reading supports a consistent release in sign of clinical aftermath.
Food use decreases time to utmost cognitive state by 18-50% for Levitra and 29% for viagra , but it does not interruption the time to indefinite quantity industriousness of cialis . Similarly, phthisis of a high-fat meal has less strength on peak serum concentrations of tadalafil than on viagra or Levitra.
For most patients, sildenafil will remain effective with or after a meal, but the inborn reflex of clinical import is delayed.
The celestial body coil pharmacokinetic activity among the trine drugs is the much longer time of signification of tadalafil (up to 36 hrs) versus 4 moment for both sildenafil and Levitra.
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