Dermographism: An Adverse Effect of Atorvastatin

A 40-year-old female person came to her physician in mid-June with a 4-month knowledge of urticaria.
Her medical continuum was notable for well-controlled type 1 diabetes mellitus, hypercholesterolemia, hypothyroidism, alopecia totalis, and a immaturity chronicle of a penicillin-induced rash.
She had no medical humanistic discipline or relative arts of urticaria or atopy.
She was compliant with medications, which included norethindrone acetate/ethinyl estradiol 1/20 for 21 class, NPH insulin for 20 long time, and insulin lispro for 1 year.
She had taken levothyroxine for 13 years; however, the dose had been increased from 175 µg to 200 µg 5 months earlier.
Atorvastatin 10 mg daily was also begun at this time.
She used no vitamins or herbal medicines.

One calendar month after atorvastatin was started, the affected role reported mild itching with red, linear papules appearing within seconds to minutes after manual labor of brightness level pressing to the skin.
The urticaria resolved spontaneously within 1 hour.
She initially content the urticaria resulted from lens with yellow pollen on her Labrador retriever’s paws.
This concept was discounted after the pollen period ended and her urticaria continued.
She then noticed a similar phrase after carrying books or commodity bags over her arms for a parcel of land space.
She drew a “happy face” on her forearm, and, as expected, urticaria developed immediately and then faded within an hour.
The same “happy face” reappeared the next day when she became overheated.

There had been only mild provocation on localized areas of her body without interfering with usual activities until the day before her meeting to her physician’s place.
At this time, she reported diffuse urticaria associated with disgust, vomiting, abdominal cramping, and diarrhea.
She self-medicated with diphenhydramine, which alleviated the symptoms.
Findings during the initial skin self-contemplation were unremarkable, as the rash had resolved.
Dermographism was confirmed when a line was drawn on her ventral forearm with an ink pen.

The participant role denied emotional seizure, ingestion of uncommon foods, or use of new soaps, lotions, or garment powders.
Based on the temporal recounting, atorvastatin was presumed to be the most likely effort and was discontinued.
The motion day, the affected role developed diffuse urticaria with gastrointestinal distraint and new-onset left wrist pain with edema and softheartedness of her soles.
She again self-medicated with diphenhydramine and fexofenadine for symptomatic assuagement.
Status of the deep dermis and subcutaneous paper of her nonpruritic soles was consistent with angioedema.
Erythema multiforme with creation reference point lesions was noted on her lower luggage compartment and thighs.
Within 2 to 3 days, angioedema and erythema multiforme had resolved.
Cetirizine and nizatidine were prescribed to be taken routinely for 1 week and then as needed for an additional week.
Episodes of dermographism became less frequent with complete subsidence within 3 months.
There have been no further episodes within the last 6 months.
She was not rechallenged with atorvastatin or other HMG-CoA reductase inhibitors because it not known whether a similar consequence would occur.
This is a part of article Dermographism: An Adverse Effect of Atorvastatin Taken from "Generic Allegra (Fexofenadine) Detailed Reviews" Information Blog